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Idea

Melody One

A four-measure rhythm-guitar progression with a two-note guitar melody above it.

Rhythm guitar

4/4 time. Each box is one measure; each chord shown takes one beat.

Measure 1
CDGG
Measure 2
CDGG
Measure 3
CEmFF
Measure 4
FFFF

Second guitar

Play the two listed strings together over each rhythm chord.

Melody guitar tab

The chord names underneath show what the rhythm guitar plays. Timing and strumming are intentionally left open.

Working note

I charted measure 3 as one beat of C, one beat of Em, and two beats of F. That matches the pattern you described and lands naturally on the full measure of F.